University of Nevada, Las Vegas

Brager Lab

Publications

  • Hewitt LT, Pagtama K, and Brager DH. Higher hyperpolarization activated current (Ih) in a subpopulation of hippocampal stratum oriens CA1 interneurons in Fragile X mice. submitted. Available on BioRxiv:doi: https://doi.org/10.1101/2022.12.20.521268
  • Parkins E, Brager DH, Rymer JK, Burwinkel JM, Rojas D, Tiwari D, Hu Y-C, and Gross C. MiR-324-5p regulates the structure of dendritic spines and is essential for hippocampal long-term potentiation submitted. Available on BioRxiv: doi: https://doi.org/10.1101/2023.07.19.549725
  • Brandalise F, Kalmbach BE, Cook EP, and Brager DH. (2023) Reduced dendritic Na+ current impairs dendritic spike generation in L5 PFC neurons in a mouse model of Fragile X syndrome. Journal of Physiology. 601(4): 831-845, doi: 10.1113/JP283311. PMID: 36625320
  • Routh BR, Brager DH, and Johnston D. (2022) Ionic and morphological contributions to the variable gain of membrane responses in layer 2/3 pyramidal neurons of mouse primary visual cortex. Journal of Neurophysiology, 128(4): 1040-1050. PMCID: PMC9576169.
  • Ordemann G, Apgar C, Chitwood RA and Brager DH. (2021) Altered A-type potassium channel function impairs dendritic spike initiation and temporammonic long-term potentiation in Fragile X syndrome. Journal of Neuroscience 41(27): 5947-62. PMID: 34083256
  • Hewitt LT, Ordemann G, and Brager DH. (2021) High and low expression of the hyperpolarization activated current (Ih) in mouse CA1 stratum oriens interneurons. Physiological Reports. May;9(9):e14848. doi: 10.14814/phy2.14848.
  • Kalmbach BE and Brager DH. (2020) Fragile X Mental Retardation Protein modulates somatic D-type K+channels and action potential threshold in the mouse prefrontal cortex. Journal of Neurophysiology. 124:1766-1773. PMID: 32997566.
  • Brandalise F, Kalmbach BE, Mehta P, Thornton O, Johnston D, Zemelman BV and Brager DH. (2020) FMRP bidirectionally controls dendritic Ih in a cell-type specific manner between mouse hippocampus and prefrontal cortex. Journal of Neuroscience, 40(27):5327-5340. PMCID: PMC7329306
  • Ordemann G, Apgar C, and Brager DH. (2019) D-type potassium channels normalize action potential firing between dorsal and ventral CA1 neurons of the mouse hippocampus. Journal of Neurophysiology 121(3): 983-995. PMID: 30673366
  • Tiwari D, Brager DH, Rymer JK, Bunk AT, White AR, Elsayed NA, Krzeski JC, Snider A, Schroeder Carter LM, Danzer SC, and Gross C. (2019) MicroRNA inhibition upregulates hippocampal A-type K+ current and reduces seizure frequency in a mouse model of epilepsy. Neurobiology of Disease, 130:104508. PMID: 31212067
  • Routh B, Rathour R, Baumgartner M, Kalmbach BE, Johnston D and Brager DH. (2017) Increased transient Na+ conductance and action potential output in layer 2/3 prefrontal cortex neurons of the fmr1−/y mouse.Journal of Physiology. 595: 4431-4448, 2017. doi: 10.1113/JP274258. PMID: 28370141
  • Kim CS, Brager DH, and Johnston D. (2017) Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress. Molecular Psychiatry. 23(4): 892-903. PMID: 28416809
  • Kalmbach BE, Johnston D, and Brager DH. (2015) Cell-type specific channelopathies in the prefrontal cortex of the fmr1-/y mouse model of Fragile X syndrome. E Neuro 2(6). pii: ENEURO.0114-15.2015. doi: 10.1523/ENEURO.0114-15. PMID: 26601124
  • Sosanya NM, Brager DH, Wolfe S, Nierre F, Raab-Graham KF. (2015) Rapamycin reveals an mTOR-independent repression of KV1.1 expression during epileptogenesis. Neurobiology of Disease, 73: 96-105. PMID: 25270294
  • Routh B, Johnston D, and Brager DH. (2013) Loss of function A-type K+ channels in the dendrites of CA1 pyramidal neurons from a mouse model of Fragile X syndrome. Journal of Neuroscience 33(50): 19442-19450. PMID: 24336711
  • Brager DH, Lewis AS, Chetkovich DM, Johnston D. (2013) Short- and long-term potentiation in CA1 neurons from a mouse lacking the h-channel auxiliary subunit TRIP8b. Journal of Neurophysiology, 110(10): 2350-2357. PMID: 23966674
  • Brager DH, Akhavan AR, and Johnston D. (2012) Impaired dendritic expression and plasticity of h-channels in the fmr1-/y mouse model of Fragile X syndrome. Cell Reports 1(3): 225-233. PMCID: PMC3363364
  • Lewis AS, Vaidya SP, Blaiss CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, Van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM. (2011) Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Journal of Neuroscience 31(20): 7424-7440. PMCID: PMC3169171
  • Shin M, Brager DH, Jaramillo TC, Johnston D, and Chetkovich DM. (2008) Redistribution of h-channels increases excitability in temporal lobe epilepsy. Neurobiology of Disease, 32(1): 26-36. PMCID: PMC2626192
  • Brager DH and Johnston D. (2007) Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in Ih in hippocampal CA1 pyramidal neurons. Journal of Neuroscience27(51): 13926-13937. PMID: 18094230
  • Fan Y†, Fricker D†, Brager DH, Chen X, Chitwood RA, Johnston D. (2005) Activity-dependent regulation of intrinsic excitability in hippocampal CA1 pyramidal neurons. Nature Neuroscience 8(11):1542-1551. †These authors contributed equally to this study. PMID: 16234810
  • Heinbockel T†, Brager DH†, Reich C, Zhao J, Muralidharan S, Kao JPY, and Alger BE. (2005) Endocannabinoid signaling dynamics probed with optical tools. Journal of Neuroscience 25(41): 9449-9459. †These authors contributed equally. PMID: 16221855
  • Brager DH Luther PW, Erdélyi F, Szabó G and Alger BE. (2003) Regulation of exocytosis from single visualized GABAergic boutons in hippocampus. Journal of Neuroscience 23(33): 10475-10486. PMID: 14627631
  • Brager DH, Cai X and Thompson SM. (2003) Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation. Nature Neuroscience 6(6): 551-552. PMID: 12754518
  • Brager DH and Thompson SM. (2003) Activity-dependent release of adenosine contributes to short-term depression at CA3-CA1 synapses in rat hippocampus. Journal of Neurophysiology 89(1): 22-26. PMID: 12522156
  • Brager DH, Capogna M, and Thompson SM. (2002) Short-term synaptic plasticity, simulation of nerve terminal dynamics, and the effect of protein kinase C activation in rat hippocampus. Journal of Physiology (Lond)541(2): 545-559. PMCID: PMC2290341
  • Varma N, Brager D, Morishita W, Lenz RA, London B, and Alger BE. (2002) Presynaptic mechanisms of DSI expression in hippocampus. Neuropharmacology 43(4): 550-562. PMID: 12367601
  • Brager DH, Sickel MJ, and McCarthy MM. (2000) Sex differences in calbindin-D28K and calretinin immunoreactivity in the neonatal rat hypothalamus. Journal of Neurobiology 42(3): 315-322. PMID: 10645971
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